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Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography

Yong Xu, Nicusor Iftimia, Huabei Jiang, L. Lyndon Key, and Marcy B. Bolster

Open Access Open Access

Abstract

We present what is believed to be the first absorption and scattering images of in vitro and in vivo bones and joints from continuous-wave tomographic measurements. Human finger and chicken bones embedded in cylindrical scattering media were imaged at multiple transverse planes with Clemson multi-channel diffuse optical imager. Both absorption and scattering images were obtained using our nonlinear, finite element based reconstruction algorithm. This study shows that diffuse optical tomography (DOT) has the potential to be used for detection and monitoring of bone and joint diseases such as osteoporosis and arthritis.

©2001 Optical Society of America

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Figures (4)
Fig. 1:
Fig. 1: Schematic of the DOT system.

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Fig. 2:
Fig. 2: (a) schematic of our test configuration including the solid phantom, chicken bones, and measurement planes. (b) schematic of the finger measurement configuration.

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Fig. 3:
Fig. 3: Reconstructed µa (mm-1, absorption) and µs′ (mm-1, reduced scattering) images from phantom/bones measurements. (a) and (b): images at measurement plane 1. (c) and (d): images at measurement plane 2.

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Fig. 4:
Fig. 4: Reconstructed µa (mm-1, absorption) and µs′ (mm-1, reduced scattering) images from the in vivo measurements obtained around the proximal interphalangeal (PIP) joint of the index finger (the pinkish region corresponds to the finger; the bluish background corresponds to the solid phantom). (a) and (b): images at the joint plane. (c) and (d): images at the off-joint/bone plane.

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