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Design and evaluation of a continuous-wave diffuse optical tomography system

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Abstract

Diffuse optical tomography (DOT) can image spatial variations in highly scattering optical media. We have built an inexpensive and portable continuous-wave DOT system containing 18 laser diode sources (9 at 780nm and 9 at 830nm) and 16 silicon detectors, which can acquire 288 independent measurements in less than 4 seconds. These data can then be processed using a variety of imaging algorithms. We first discuss the design of diffuse imaging equipment in general, and then describe our instrument, along with the technical issues that influenced its design. The technical challenges involved in performing DOT over large optode areas are discussed. We also present rat brain measurements following electrical forepaw stimulation using DOT. These results clearly demonstrate the capabilities of DOT and set the stage for advancement to quantitative functional brain imaging.

©1999 Optical Society of America

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Figures (3)

Fig. 1.
Fig. 1. A block diagram of the prototype DOT imager. All functions, including source and detector selection, are computer-controlled.
Fig. 2.
Fig. 2. DOT images of rat brain function at the peak response following 45 seconds of electrical forepaw stimulation. The recovery to baseline is shown 50 seconds following cessation of activation. Dark blue represents a change in the absorption coefficient of 0 cm-1 while dark red represents a change of 0.004 cm-1.
Fig 3.
Fig 3. The schematic diagram of a single detector phase diversity prototype system. A four-channel version was developed to evaluate phase diversity in more complex two-wavelength systems.

Tables (2)

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Table 1. Our performance goals for the prototype DOT imager.

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Table 2. Results of the measurements performed on the prototype DOT imager.

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