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Three-dimensional bioluminescence tomography with model-based reconstruction

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Abstract

A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

©2004 Optical Society of America

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Figures (2)

Fig 1.
Fig 1. Source distribution (S(x,y,z)) images reconstructed from 748 simulated measurement data: (a) Exact image of the single target. (b) Reconstructed image of the single target. (c) A cross sectional image of the single target at X=10mm. (d) Exact image of the two targets. (e) Reconstructed image of the two targets. (f) A cross sectional image at Z=10mm of the two targets. The axes illustrate the spatial scale, in
Fig. 2.
Fig. 2. Source distribution (S(x,y,z)) image of a single target reconstructed from 480 experimental data measured from the luciferase-luciferin containing phantom. (a) Exact image. (b) Reconstructed image. (c) A cross sectional image at X=10mm. The axes illustrate the spatial scale, in millimeters, whereas the color bar records the source coefficient (arbitrary units).

Equations (5)

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· D Φ ( x , y , z ) μ a Φ ( x , y , z ) = S ( x , y , z )
D Φ . i ̂ n = α Φ
[ A ] { Φ } = { b }
[ A ] { Φ S } = { b S }
( T + λ I ) Δ S = T ( Φ ( m ) Φ ( c ) )
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