Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
Journal Home About Issues in Progress Current Issue All Issues Feature Issues

Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source

Tony H. Ko, Desmond C. Adler, James G. Fujimoto, Dmitry Mamedov, Viatcheslav Prokhorov, Vladimir Shidlovski, and Sergei Yakubovich

Open Access Open Access

Abstract

Ultrahigh resolution optical coherence tomography imaging is performed with a compact broadband superluminescent diode light source. The source consists of two multiplexed broadband superluminescent diodes and has a power output of 4 mW with a spectral bandwidth of 155 nm, centered at a wavelength of 890 nm. In vivo imaging was performed with approximately 2.3 μm axial resolution in scattering tissue and approximately 3.2 μm axial resolution in the retina. These results demonstrate that it is possible to perform in vivo ultrahigh resolution optical coherence tomography imaging using a superluminescent diode light source that is inexpensive, compact, and easy to operate.

©2004 Optical Society of America

Full Article  |  PDF Article
More Like This
Ultrahigh-resolution optical coherence tomography with a diode-pumped broadband Cr3+:LiCAF laser

Philipp C. Wagenblast, Tony H. Ko, James G. Fujimoto, Franz X. Kaertner, and Uwe Morgner
Opt. Express 12(14) 3257-3263 (2004)

Optical coherence tomography using a continuous-wave, high-power, Raman continuum light source

Pei-Lin Hsiung, Yu Chen, Tony H. Ko, James G. Fujimoto, Christiano J.S. de Matos, Sergei V. Popov, James R. Taylor, and Valentin P. Gapontsev
Opt. Express 12(22) 5287-5295 (2004)

Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources

Barry Cense, Eric Koperda, Jeffrey M. Brown, Omer P. Kocaoglu, Weihua Gao, Ravi S. Jonnal, and Donald T. Miller
Opt. Express 17(5) 4095-4111 (2009)

View More...

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (6)
Fig. 1.
Fig. 1. Schematic of the OCT system using a broadband SLD light source for in vivo ultrahigh resolution OCT imaging. A single detector was used due to the low excess noise of the SLD source. Dispersion matching elements (BK7, FS) in the reference arm were used to match the dispersion of optical elements in the sample arm. Polarization controllers (PC) allowed polarization adjustments to maximize field intensity in the interferometer.

Download Full Size | PDF

Fig. 2.
Fig. 2. (a) Individual output spectra of the two superluminescent diodes. (b) Fiber-coupled multiplexed spectrum of the broadband SLD source. (c) Coherence point spread function of the broadband SLD source. (d) Logarithmic demodulated coherence point spread function. A 3.0 OD filter was used to prevent detector saturation.

Download Full Size | PDF

Fig. 3.
Fig. 3. In vivo ultrahigh resolution OCT image of the Syrian golden hamster cheek pouch taken with the broadband SLD light source. Image axial resolution was 2.3 μm in tissue and transverse resolution was 5 μm. Ultrahigh resolution OCT imaging using a broadband SLD light source is capable of visualizing the stratum cornium, epithelium, muscularis, connective tissue, and blood vessels in the hamster cheek pouch.

Download Full Size | PDF

Fig. 4.
Fig. 4. In vivo ultrahigh resolution OCT image of the human retina taken with the broadband SLD light source. Image axial resolution in the retina was about 3.2 μm and transverse resolution was about 15–20 μm. All the major intraretinal layers can be clearly seen in this ultrahigh resolution OCT image.

Download Full Size | PDF

Fig. 5.
Fig. 5. In vivo standard resolution OCT image of the human retina taken with the commercial StratusOCT clinical system. Axial resolution of the image was about 10 μm and transverse resolution was about 20 μm. Small intraretinal features such as the ganglion cell layer and the external limiting membrane are not as clearly visualized as in the ultrahigh resolution image (Fig. 4).

Download Full Size | PDF

Fig. 6.
Fig. 6. Foveal region enlargements (2x) of the ultrahigh resolution OCT and standard resolution OCT images of the human retina. Ultrahigh resolution OCT has the ability to improve visualization and delineation of small intraretinal features over standard resolution OCT. Retinal features such as the external limiting membrane (ELM) and ganglion cell layer (GCL) are much better visualized in the ultrahigh resolution OCT image.

Download Full Size | PDF

Select as filters
Select Topics Cancel
Top
       
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.
Privacy | Terms of Use